Although scientists are working to develop a safe, effective vaccine for gonorrhea, no vaccine exists at this time. However, women can help prevent gonorrhea by practicing safe sex. This includes always using latex condoms during sex, minimizing the number of sexual partners, knowing the sexual history of sexual partners and testing for sexually transmitted diseases (STDs). The use of a latex dental dam during oral sex can minimize the risk of contracting gonorrhea in the throat. Abstinence from all sexual activity can completely prevent the disease.

Regular gynecological examinations and frank discussions with physicians about sexual activity can help women monitor their health and exposure to gonorrhea and other sexually transmitted diseases. STD testing is not standard for gynecological exams, so women should request tests if they are concerned about their exposure.

Pregnant women should be tested for gonorrhea and treated if necessary. Babies born in hospitals are treated with silver nitrate eyedrops to prevent gonorrhea in their eyes.